Immune System

Living with 22q
Children born with the 22q Deletion syndrome (also known as DiGeorge syndrome or velocardiofacial syndrome), may have a weaker immune system compared to other children.  This means that they may have more difficulty “fighting off” infections.  Fortunately, the majority of children with 22q Deletion Syndrome will not develop any serious immune problems.

Until your child has had a proper immunology assessment, you should take the following precautions:

  • Your child should not receive any live viral vaccines, such as measles, mumps, rubella, oral polio or chicken pox vaccine.

  • If your child needs to receive a blood product (a blood transfusion), it must be negative for the cytomegalovirus (CMV) and irradiated.  Have your doctor check with an immunologist prior to any blood product administration.

  • If your child is exposed to chicken pox, he/she may need to receive Zoster Immune Globulin, an injection of antibodies against chicken pox that modifies the course or may protect children for 30 days from developing the disease. Children need to receive the injection at every exposure that occurs more than 30 days since the last injection.

  • If your child develops chicken pox, your doctor should consult with an immunologist, as your child may need an antiviral medication. 

These precautions should be followed until your child has had an immunology assessment.  At that point, your immunologist will make recommendations that are specific to your child’s situation. 

The 10 Warning Signs of Primary Immune Deficiency

Talk to your doctor about the possibility of primary immunodeficiency disease if your child has more than one of the following:

  • Eight or more ear infections within one year

  • Two or more serious sinus infections within one year

  • Two or more months on antibiotics with little or no affect       
  • Two or more pneumonias within one year        
  • Failure of an infant to gain weight or grow normally

  • Recurrent, deep skin or organ abscesses

  • Persistent thrush in mouth or elsewhere on skin, after age one

  • Need for intravenous antibiotics to clear infections

  • Two or more deep seated infections

  • A family history of primary immune deficiency

Calcium Regulation
Immune System